The Mets topped the Cubs, 9-4, in Las Vegas on Saturday.
Ryan Reid relieved Colon, allowing inherited runners to score.
The Mets clubbed seven doubles and a home run. Wilmer Flores homered, driving in two.
Andrew Brown went 2-3 with 3 RBI. David Wright picked up 2 RBI.
Cory Mazzoni struck out three in his one inning of work.
To get a full recap and boxscore, go to SNY.TV.
The split-squad Mets will play two games Sunday, with one half of the team facing the Cubs in in Las Vegas, while the other half will play the Cardinals in Jupiter.